Publications and Current Funding

from UNC Asheville *Indicated Undergraduate Co-Author, **Indicated NCSSM High School Co-author
  1. Ward, K. T.;* Williams, A. P. L.;* Blair, C. A.;** Chatterjee, A. M.;** Karthikeyan,A.;** Roper, A. S.;** Kellogg, C. N.:* Steed, P. R.;‡ Wolfe, A. L.‡ Amine basicity of quinoline ATP synthase inhibitors drives antibacterial activity against Pseudomonas aeruginosa. ACS Medicinal Chemistry Letters, 2024, 15(1), 149-155. https://doi.org/10.1021/acsmedchemlett.3c00480
  2. Fraunfelter, V. M.;* Pugh, B. A.;* Williams, A. P. L.;* Ward, K. T.;* Jackson, D. O.;*  Austin, M.;* Ciprich, J. F.;* Dippy, L.;* Dunford, J.;* Edwards, G. N.;* Glass, E.;* Handy, K. M.;* Kellogg, C. N.;* Llewellyn, K.;* Nyberg, K. Q.;* Shepard, S. J.;* Thomas, C.;* Wolfe, A. L; ‡ Steed, P. R. ‡ Quinoline compounds targeting the c-ring of ATP synthase inhibit drug-resistant Pseudomonas aeruginosa. ACS Infectious Diseases 2023, 9 (12), 2448–2456. https://doi.org/10.1021/acsinfecdis.3c00317
  3. Kellogg, C. N.;* Pugh, B. A.;* Starr, I. M.;* Parmar, D. J.;* Troxler, A. D.;* Wolfe, A. L.‡ “Bisbenzamidine and Bisbenzguanidine Ureas Act as Antibacterial Agents Against Pseudomonas aeruginosa” ChemMedChem 2023, e202300496. https://doi.org/10.1002/cmdc.202300496
  4. Park, J.; Mahida, N.; Ho, G.; Pena, E.; Makabenta, J. M. V.; Aneke, S.; Jiange, M.; Bouthillette, L. M.;* Holz, S. E.;* Hassan, M. H.; Wolfe,A. L.; Vincent M. Rotello, V. M.‡ Integration of antimicrobials and delivery systems: Synergistic antibiofilm activity with biodegradable nanoemulsions incorporating pseudopyronine analogs. Antibiotics 2023, 12(8), 1240. Invited, Special Issue Design and Synthesis of Novel Antibiotics. https://doi.org/10.3390/antibiotics12081240
  5. Wolfe, A. L.;‡ Steed, P. R. “Generating Publishable Data from Course-Based Undergraduate Research Experiences in Chemistry” Journal of Chemical Education 2023, 100, 3419-3424. https://doi.org/10.1021/acs.jchemed.3c00354
  6. Murphy, K. E.; Thacher, M. K.;* Young, E. C;* Mojik, V.;* Wolfe, A. L. “Total Synthesis and Antibacterial Evaluation of Empetroxepins A and B and related analogs.” Bioorg. Med. Chem. Lett. 2022, 75, 128955. https://doi.org/10.1016/j.bmcl.2022.128955.
  7. Ciprich, J. F.;* Buckhalt, A. J. E.;* Carroll, L. L.;* Chen, D.;* DeFiglia, S. A.;* McConnell, R. S.;* Parmar, D. J.;* Pistor, O. L.;* Rao, A. B.* Rubin, M. L.;* Volk, G. E.;* Steed, P. R.; Wolfe, A. L.‡“Synthesis and Evaluation of Pseudomonas aeruginosa ATP Synthase Inhibitors.” ACS Omega 2022, 7(32), 28434–28444. DOI: 10.1021/acsomega.2c03127
  8. Pugh, B. A.;* Rao, A. B.;* Angeles-Solano, M.;* Grosser, M. R.; Murphy, K. E.; Wolfe, A. L. Development of poly-nitrogenous pentamidine-like adjuvants capable of potentiating antibiotics in Gram-negative bacteria” RSC Medicinal Chemistry 2022,accepted. DOI: 10.1039/D2MD00041E
  9. Murphy, K. E.; Sloan, G. F.;* Lawhern, G. V.;* Volk, G. E.;* Shumate, J. T.;* Wolfe, A. L. Advances in antibiotic drug discovery: Reducing the barriers for antibiotic development” Future Medicinal Chemistry 2020, 12(22), 2067-2087. https://www.future-science.com/doi/10.4155/fmc-2020-0247.
  10. Fields, L.;* Craig, W. R.; Huffine, C. A.;* Allen, C. F.;* Bouthillette, L. M.;* Chappell, J. C.;* Shumate, J. T.;* Wolfe, A. L. “Short chain alpha-pyrones capable of potentiating penicillin G against Pseudomonas aeruginosa” Bioorganic and Medicinal Chemistry Letters 2020, 30(16), 127301.
  11. Fields, L.;* Craig, W. R.; Wasileski, S. A.; Wolfe, A. L.“Effects of Shade on Antibacterial Production in Aloe VeraPlants: A Model Course Based Undergraduate Research Experience for First- and Second-Year Chemistry and Biochemistry Students” World Journal of Chemical Education 2019, 7, 248. 
  12. Murray, E. M.;* Allen, C. F.;* Handy, T. E.;* Huffine, C. A.;* Craig, W. R.; Seaton, S. C.; Wolfe, A. L. “Development of a Robust and Quantitative High Throughput Screening Method for Antibiotic Production in Bacterial Libraries” ACS Omega  2019, 4, 15414. 
  13. Bouthillette, L. M.;* Darcey, C. A.;* Handy, T. E.;* Seaton, S. C.; Wolfe, A. L. Isolation of the Antibiotic Pseudopyronine B and SAR Evaluation of C3/C6 Alkyl Analogs. Bioorg. Med. Chem. Lett. 2017, 27(12), 2762.
Prior to UNC Asheville
  1. Wolfe, A. L.; Duncan, K. K.; Lajiness, J. P.; Zhu, K.; Duerfeldt, A. Boger, D. L.A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin SA class of antitumor drugs: hydrophobic binding-driven-bonding. J. Med. Chem.  2013, 56, 6845.
  2. Wolfe, A. L.; Duncan, K. K.; Parelkar, N. K.; Weir, S. J.; Vielhauer, G. A.; Boger, D. L. Efficacious cyclic N-acylO-amino phenol duocarmycin prodrugs.J. Med. Chem.2013, 56, 4104.
  3. Vielhauer, G. A.;Swink,M.; Parelkar,N. K.; Lajiness,J. P.; Wolfe,A. L.;Boger, D. L. Characterization of a duocarmycin prodrug against solid cancers. Cancer Biology and Therapy2013, 14, 527.
  4. Xie, J.; Wolfe, A. L.; Boger, D. L. Total synthesis of kopsinine. Org. Let.2013, 15, 868.
  5. Wolfe, A. L.; Duncan, K. K.; Parelkar, N. K.; Weir, S. J.; Vielhauer, G. A.; Boger, D. L. A novel, unusually efficacious duocarmycin carbamate prodrug that releases no residual byproductJ. Med. Chem.2012, 55, 5878.
  6. Ballard, T. E.; Richards, J. J.; Wolfe, A. L.; Melander, C. Synthesis     and anti-biofilm activity of a second generation reverse amide oroidin library: an SAR study.Chem. Eur. J.  2008, 14, 10745.
  7. Mammana, A.; Asakawa, T.; Bitsch-Jensen, K.; Wolfe, A.; Chaturantabut, S.; Otani, Y.; Li, X.; Li, Z.; Nakanishi, K.; Balaz, M.; Ellestad, G. A.; Berova, N. Synthesis and characterization of water-soluble free-base, zinc and copper porphyrin-oligonucleotide conjugates. Bioorg. Med. Chem. 2008, 16, 6544.Wolfe, A. L.; Duncan, K. K.; Lajiness, J. P.; Zhu, K.; Duerfeldt, A. Boger, D. L.A fundamental relationship between hydrophobic properties and biological activity for the duocarmycin SA class of antitumor drugs: hydrophobic binding-driven-bonding. J. Med. Chem.  2013, 56, 6845.
Current Funding
  • Henry Dreyfus Teacher Scholar Award. $75,000. 2024-2029.
  • National Institutes of Health Academic Research Enhancement Award (R15) – Amanda Wolfe (PI), P. Ryan Steed (co-PI), “Targeted development and selective delivery of small molecule antibiotics for the treatment of multidrug resistant Pseudomonas aeruginosa infections” $384,353. 08/01/2021-07/31/2024. 
Prior Funding
  • Research Corporation For Science Advancement-Cottrell Scholar Award – Amanda Wolfe (PI), “Improving Antibacterial Drug Discovery through Mixed Microbial Culture and Synthetic Organic Chemistry.” Amount: $100,000. July 2017 – December 2021.
  • The Cannon Foundation Grant – Tim Elgren (PI) with Amanda Wolfe (Senior Personnel) and John Brock (Senior Personnel), “Instrumentation Support for UNC Asheville STEM Initiative.” June 2020-July 2021
  • North Carolina GlaxoSmithKline Foundation – Keith Krumpe (PI), Amanda Wolfe (Senior Personnel), Thomas Meigs (Senior Personnel), Herman Holt Jr. (Senior Personnel), Sarah Seaton (Senior Personnel), “The NC GlaxoSmithKline Foundation Chemistry & Biology Fellows & Scholars Program: A Five-Year Project to Fortify and Diversify Undergraduate Medicinal Chemistry, Biochemistry, and Chemical & Molecular Biology Research at UNC Asheville.” Amount $2,276,004. June 2016 – May 2021.
  • North Carolina Biotechnology Center-Biotechnology Research Grant – Amanda Wolfe (PI), Sarah Seaton (co-PI, Biology Department) “Isolation, synthesis, and interrogation of natural product based antibacterial agents.” $109,930. Pre-proposal Submitted 9/17/14 and was invited to submit a full proposal. July 2015 – December 2018